Performance of creatinine-based equations to estimate glomerular filtration rate with a methodology adapted to the context of drug dosage adjustment

AIM: The Cockcroft-Gault (CG) creatinine-based equation is still used to estimate glomerular filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead to hazardous over- or underdosing. METHODS: In a cross-sectional analysis, CG was validated against measured GFR (mGFR) in 14 804 pa...

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Veröffentlicht in:	BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 2022-05, Vol.88 (5), p.2118-2127
Hauptverfasser:	Delanaye, Pierre, Bjork, Jonas, Courbebaisse, Marie, Couzi, Lionel, Ebert, Natalie, Eriksen, Bjorn O, Dalton, R. Neil, Dubourg, Laurence, Gaillard, Francois, Garrouste, Cyril, Grubb, Anders, Jacquemont, Lola, Hansson, Magnus, Kamar, Nassim, Lamb, Edmund J, Legendre, Christophe, Littmann, Karin, Mariat, Christophe, Melsom, Toralf, Rostaing, Lionel, Rule, Andrew D, Schaeffner, Elke, Sundin, Per-Ola, Berg, Ulla B, Asling-Monemi, Kajsa, Selistre, Luciano, Akesson, Anna, Larsson, Anders, Bokenkamp, Arend, Pottel, Hans, Nyman, Ulf
Format:	Artikel
Sprache:	eng
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Zusammenfassung:	AIM: The Cockcroft-Gault (CG) creatinine-based equation is still used to estimate glomerular filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead to hazardous over- or underdosing. METHODS: In a cross-sectional analysis, CG was validated against measured GFR (mGFR) in 14 804 participants and compared with the Modification-of-Diet-in-Renal-Diseases (MDRD), Chronic-Kidney-Disease-Epidemiology (CKD-EPI), Lund-Malmö-Revised (LMR) and European-Kidney-Function-Consortium (EKFC) equations. Validation focused on bias, imprecision and accuracy (percentage of estimates within ±30% of mGFR, P30), overall and stratified for mGFR, age and body mass index at mGFR
ISSN:	0306-5251