Usual interstitial pneumonia in ANCA-associated vasculitis: A poor prognostic factor

Usual interstitial pneumonia in ANCA-associated vasculitis: A poor prognostic factor

BACKGROUND: Progressive fibrosing interstitial lung disease (ILD) is rarely associated with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). This study focused on the outcomes of ILD patients with associated AAV (AAV-ILD). METHODS: AAV-ILD (cases: microscopic polyangiitis (MPA)...

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Veröffentlicht in:JOURNAL OF AUTOIMMUNITY 2020-01, Vol.106
Hauptverfasser: Maillet, Thibault, Goletto, Tiphaine, Beltramo, Guillaume, Dupuy, Henry, Jouneau, Stephane, Borie, Raphael, Crestani, Bruno, Cottin, Vincent, Blockmans, Daniel, Lazaro, Estibaliz, Naccache, Jean-Marc, Pugnet, Gregory, Nunes, Hilario, de Menthon, Mathilde, Devilliers, Herve, Bonniaud, Philippe, Puechal, Xavier, Mouthon, Luc, Bonnotte, Bernard, Guillevin, Loic, Terrier, Benjamin, Samson, Maxime, Andre, M, Bielefed, P, Delaunay, Blanchard, Brihaye, B, Groh, M, Kisterman, J.P, Koenig, M, Lavigne, C, Limal, N, Maurier, F, Mausservey, C, Pertuiset, E, Rebibou, J.M, Saraux, J.L, Tazi, A
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Sprache:eng
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Zusammenfassung:BACKGROUND: Progressive fibrosing interstitial lung disease (ILD) is rarely associated with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). This study focused on the outcomes of ILD patients with associated AAV (AAV-ILD). METHODS: AAV-ILD (cases: microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA) with ILD) were compared to AAV patients without ILD (controls). ILD was defined as a usual interstitial pneumonia (UIP) or non-specific interstitial pneumonia (NSIP) pattern. Two controls were matched to each case for age (>or ≤65 years), ANCA status (PR3-or MPO-positive) and creatininemia (≥or 65 years (hazard ratio (HR) 4.54; p 
ISSN:0896-8411