Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils

Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils

Recent structural studies show distinct morphologies for the fibrils of Aβ(1-42) and Aβ(1-40), which are believed not to co-fibrillize. We describe here a novel, structurally-uniform 1 : 1 mixed fibrillar species, which differs from both pure fibrils. It forms preferentially even when Aβ(1-42) : Aβ(...

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Veröffentlicht in:CHEMICAL COMMUNICATIONS 2020-08, Vol.56 (62), p.8830-8833
Hauptverfasser: Cerofolini, Linda, Ravera, Enrico, Bologna, Sara, Wiglenda, Thomas, Boeddrich, Annett, Purfuerst, Bettina, Benilova, Iryna, Korsak, Magdalena, Gallo, Gianluca, Rizzo, Domenico, Gonnelli, Leonardo, Fragai, Marco, De Strooper, Bart, Wanker, Erich E, Luchinat, Claudio
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Sprache:eng
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Zusammenfassung:Recent structural studies show distinct morphologies for the fibrils of Aβ(1-42) and Aβ(1-40), which are believed not to co-fibrillize. We describe here a novel, structurally-uniform 1 : 1 mixed fibrillar species, which differs from both pure fibrils. It forms preferentially even when Aβ(1-42) : Aβ(1-40) peptides are mixed in a non-stoichiometric ratio.
ISSN:1359-7345