Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis

Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis

BACKGROUND: More effective and safer treatments are needed for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. METHODS: We conducted a randomized trial with a 2-by-2 factorial design to evaluate the use of plasma exchange and two regimens of oral glucocorticoids in patients with se...

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Veröffentlicht in:N Engl J Med 2020-02, Vol.382 (7), p.622-631
Hauptverfasser: Walsh, Michael, Merkel, Peter A, Peh, Chen-Au, Szpirt, Wladimir M, Puéchal, Xavier, Fujimoto, Shouichi, Hawley, Carmel M, Khalidi, Nader, Floßmann, Oliver, Wald, Ron, Girard, Louis P, Levin, Adeera, Gregorini, Gina, Harper, Lorraine, Clark, William F, Pagnoux, Christian, Specks, Ulrich, Smyth, Lucy, Tesar, Vladimir, Ito-Ihara, Toshiko, de Zoysa, Janak Rashme, Szczeklik, Wojciech, Flores-Suárez, Luis Felipe, Carette, Simon, Guillevin, Loïc, Pusey, Charles D, Casian, Alina L, Brezina, Biljana, Mazzetti, Andrea, McAlear, Carol A, Broadhurst, Elizabeth, Reidlinger, Donna, Mehta, Samir, Ives, Natalie, Jayne, David R.W, PEXIVAS Investigators
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Sprache:eng
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Zusammenfassung:BACKGROUND: More effective and safer treatments are needed for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. METHODS: We conducted a randomized trial with a 2-by-2 factorial design to evaluate the use of plasma exchange and two regimens of oral glucocorticoids in patients with severe ANCA-associated vasculitis (defined by an estimated glomerular filtration rate of
ISSN:0028-4793