Long-term effects of adjunctive perampanel on cognition in adolescents with partial seizures

Long-term effects of adjunctive perampanel on cognition in adolescents with partial seizures

OBJECTIVE: The aim of this study was to evaluate long-term effects of adjunctive perampanel on cognition, efficacy, growth, safety, and tolerability in adolescents with inadequately controlled partial seizures. METHODS: Study 235, a multicenter, randomized, double-blind, placebo-controlled, parallel...

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Veröffentlicht in:EPILEPSY & BEHAVIOR 2018-06, Vol.83, p.50-58
Hauptverfasser: Pina-Garza, Jesus E, Lagae, Lieven, Villanueva, Vicente, Ben Renfroe, J, Laurenza, Antonio, Williams, Betsy, Kumar, Dinesh, Meador, Kimford J
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Sprache:eng
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Zusammenfassung:OBJECTIVE: The aim of this study was to evaluate long-term effects of adjunctive perampanel on cognition, efficacy, growth, safety, and tolerability in adolescents with inadequately controlled partial seizures. METHODS: Study 235, a multicenter, randomized, double-blind, placebo-controlled, parallel-group, Phase II study with an open-label extension phase (NCT01161524), was primarily designed to assess the effects of adjunctive perampanel on cognition. Patients (aged ≥12 to
ISSN:1525-5050