Detailed phenotyping of posterior vs. anterior circulation ischemic stroke: a multi-center MRI study

Detailed phenotyping of posterior vs. anterior circulation ischemic stroke: a multi-center MRI study

OBJECTIVE: Posterior circulation ischemic stroke (PCiS) constitutes 20-30% of ischemic stroke cases. Detailed information about differences between PCiS and anterior circulation ischemic stroke (ACiS) remains scarce. Such information might guide clinical decision making and prevention strategies. We...

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Veröffentlicht in:JOURNAL OF NEUROLOGY 2020-03, Vol.267 (3), p.649-658
Hauptverfasser: Frid, Petrea, Drake, Mattias, Giese, A.K, Wasselius, J, Schirmer, M.D, Donahue, K.L, Cloonan, L, Irie, R, Bouts, M.J.R.J, McIntosh, E.C, Mocking, S.J.T, Dalca, A.V, Sridharan, R, Xu, H, Giralt-Steinhauer, E, Holmegaard, L, Jood, K, Roquer, J, Cole, J.W, McArdle, P.F, Broderick, J.P, Jimenez-Conde, J, Jern, C, Kissela, B.M, Kleindorfer, D.O, Lemmens, R, Meschia, J.F, Rundek, T, Sacco, R.L, Schmidt, R, Sharma, P, Slowik, A, Thijs, V, Woo, D, Worrall, B.B, Kittner, S.J, Mitchell, B.D, Petersson, J, Rosand, J, Golland, P, Wu, O, Rost, N.S, Lindgren, A
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Sprache:eng
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Zusammenfassung:OBJECTIVE: Posterior circulation ischemic stroke (PCiS) constitutes 20-30% of ischemic stroke cases. Detailed information about differences between PCiS and anterior circulation ischemic stroke (ACiS) remains scarce. Such information might guide clinical decision making and prevention strategies. We studied risk factors and ischemic stroke subtypes in PCiS vs. ACiS and lesion location on magnetic resonance imaging (MRI) in PCiS. METHODS: Out of 3,301 MRIs from 12 sites in the National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network (SiGN), we included 2,381 cases with acute DWI lesions. The definition of ACiS or PCiS was based on lesion location. We compared the groups using Chi-squared and logistic regression. RESULTS: PCiS occurred in 718 (30%) patients and ACiS in 1663 (70%). Diabetes and male sex were more common in PCiS vs. ACiS (diabetes 27% vs. 23%, p 
ISSN:0340-5354