Glucocorticoid receptor DNA methylation and childhood trauma in chronic fatigue syndrome patients

Glucocorticoid receptor DNA methylation and childhood trauma in chronic fatigue syndrome patients

Although the precise mechanisms are not yet understood, previous studies have suggested that chronic fatigue syndrome (CFS) is associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation and trauma in early childhood. Consistent with findings suggesting that early life stress-induced DNA...

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Veröffentlicht in:Journal of Psychosomatic Research 2018-01, Vol.104, p.55-60
Hauptverfasser: Vangeel, Elise, Kempke, Stefan, Bakusic, Jelena, Godderis, Lode, Luyten, Patrick, Van Heddegem, Leen, Compernolle, Veerle, Persoons, Philippe, Lambrechts, Diether, Izzi, Benedetta, Freson, Kathleen, Claes, Stephan
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Sprache:eng
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Zusammenfassung:Although the precise mechanisms are not yet understood, previous studies have suggested that chronic fatigue syndrome (CFS) is associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation and trauma in early childhood. Consistent with findings suggesting that early life stress-induced DNA methylation changes may underlie dysregulation of the HPA axis, we previously found evidence for the involvement of glucocorticoid receptor (GR) gene (NR3C1) methylation in whole blood of CFS patients.
ISSN:0022-3999