Establishment and characterization of uterine sarcoma and carcinosarcoma patient-derived xenograft models

Establishment and characterization of uterine sarcoma and carcinosarcoma patient-derived xenograft models

Uterine sarcomas (US) and carcinosarcomas (CS) are rare, aggressive cancers. The lack of reliable preclinical models hampers the search for new treatment strategies and predictive biomarkers. To this end, we established and characterized US and CS patient-derived xenograft (PDX) models.

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Veröffentlicht in:Gynecologic Oncology 2017-09, Vol.146 (3), p.538-545
Hauptverfasser: Cuppens, Tine, Depreeuw, Jeroen, Annibali, Daniela, Thomas, Debby, Hermans, Els, Gommé, Ellen, Trinh, Xuan Bich, Debruyne, David, Moerman, Philippe, Lambrechts, Diether, Amant, Frédéric
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Sprache:eng
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Zusammenfassung:Uterine sarcomas (US) and carcinosarcomas (CS) are rare, aggressive cancers. The lack of reliable preclinical models hampers the search for new treatment strategies and predictive biomarkers. To this end, we established and characterized US and CS patient-derived xenograft (PDX) models.
ISSN:0090-8258