Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues

Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues

The synthesis and anti-HIV-1 activity of a series of diarylpyrimidines (DAPYs) are described. Several members of this novel class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) are extremely potent against both wild-type and a panel of clinically significant single- and double-mutant st...

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Veröffentlicht in:Bioorganic & Medicinal Chemistry Letters 2001-09, Vol.11 (17), p.2235-9
Hauptverfasser: Ludovici, D.W, De Corte, B.L, Kukla, M.J, Ye, H, Ho, C.Y, Lichtenstein, M.A, Kavash, R.W, Andries, K, de Béthune, M.P, Azijn, H, Pauwels, R, Lewi, P.J, Heeres, J, Koymans, L.M, de Jonge, M.R, Van Aken, K.J, Daeyaert, F.F, Das, Kalyan, Arnold, E, Janssen, P.A
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Sprache:eng
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Zusammenfassung:The synthesis and anti-HIV-1 activity of a series of diarylpyrimidines (DAPYs) are described. Several members of this novel class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) are extremely potent against both wild-type and a panel of clinically significant single- and double-mutant strains of HIV-1.
ISSN:0960-894X