Body weight, gender, and pregnancy affect enantiomer-specific ketorolac pharmacokinetics

Body weight, gender, and pregnancy affect enantiomer-specific ketorolac pharmacokinetics

Although ketorolac analgesia is linked only to the S-enantiomer, there is limited information on the stereo-selective pharmacokinetics of ketorolac. We studied the stereo-selective pharmacokinetics of ketorolac in a pooled dataset of two studies, with women at delivery and 4-5 months postpartum, and...

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Veröffentlicht in:British Journal of Clinical Pharmacology 2017-09, Vol.83 (9), p.1966-1975
Hauptverfasser: Välitalo, Pyry A, Kemppainen, Heidi, Kulo, Aida, Smits, Anne, Van Calsteren, Kristel, Olkkola, Klaus T, de Hoon, Jan, Knibbe, Catherijne A.J, Allegaert, Karel
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Sprache:eng
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Zusammenfassung:Although ketorolac analgesia is linked only to the S-enantiomer, there is limited information on the stereo-selective pharmacokinetics of ketorolac. We studied the stereo-selective pharmacokinetics of ketorolac in a pooled dataset of two studies, with women at delivery and 4-5 months postpartum, and males and non-pregnant females.
ISSN:0306-5251