Associations of plasma uric acid and purine metabolites with blood pressure in children: the KOALA Birth Cohort Study

Associations of plasma uric acid and purine metabolites with blood pressure in children: the KOALA Birth Cohort Study

Elevated serum uric acid concentration has been associated with high blood pressure (BP) and hypertension. A putative underlying mechanism is the accumulation of reactive oxygen species when uric acid is generated by an increased enzyme activity of xanthine oxidase (XO). The aims of the present stud...

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Veröffentlicht in:Journal of Hypertension 2017-05, Vol.35 (5), p.982-993
Hauptverfasser: Scheepers, Lieke E.J.M, Boonen, Annelies, Pijnenburg, Wieke, Bierau, Jörgen, Staessen, Jan A, Stehouwer, Coen D.A, Thijs, Carel, Arts, Ilja C.W
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Sprache:eng
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Zusammenfassung:Elevated serum uric acid concentration has been associated with high blood pressure (BP) and hypertension. A putative underlying mechanism is the accumulation of reactive oxygen species when uric acid is generated by an increased enzyme activity of xanthine oxidase (XO). The aims of the present study were to investigate the associations between plasma uric acid concentration, purine metabolite ratios, as proxies for increased XO activity, and SBP and DBP in school-age children.
ISSN:0263-6352