Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis

Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis

Insulin like growth factor (IGF)-I can act on a variety of cells involved in cartilage and bone repair, yet IGF-I has not been studied extensively in the context of inflammatory arthritis. The objective of this study was to investigate whether IGF-I overexpression in the osteoblast lineage could lea...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PLoS One 2016, Vol.11 (10)
Hauptverfasser: van Tok, Melissa N, Yeremenko, Nataliya G, Teitsma, Christine A, Kream, Barbara E, Knaup, Véronique L, Lories, Rik, Baeten, Dominique L, van Duivenvoorde, Leonie M
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 10
container_start_page
container_title PLoS One
container_volume 11
creator van Tok, Melissa N
Yeremenko, Nataliya G
Teitsma, Christine A
Kream, Barbara E
Knaup, Véronique L
Lories, Rik
Baeten, Dominique L
van Duivenvoorde, Leonie M
description Insulin like growth factor (IGF)-I can act on a variety of cells involved in cartilage and bone repair, yet IGF-I has not been studied extensively in the context of inflammatory arthritis. The objective of this study was to investigate whether IGF-I overexpression in the osteoblast lineage could lead to increased reparative or pathological bone formation in rheumatoid arthritis and/or spondyloarthritis respectively.
format Article
fullrecord <record><control><sourceid>kuleuven</sourceid><recordid>TN_cdi_kuleuven_dspace_123456789_578242</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>123456789_578242</sourcerecordid><originalsourceid>FETCH-kuleuven_dspace_123456789_5782423</originalsourceid><addsrcrecordid>eNqVyr0OgjAUQOHGaCL-vMPdHAwJtoA4qoiSGCYHN9LgNVaxNe0FfXwXB0edzhm-DvNmC8H9mAei-_V9NnDuGgSRSOLYY8dcu6ZW2t-rG8LWmiddIJMVGQs5pAYdFIYgtapFKPAJK6MRMmPvkpTRoDRsXg-06o6aZA1LSxerSLkR651l7XD86ZBNss1hvfNvTY1Ni7o8uYessJxxEUbxPFmU0TzhIRf_yOlvsqQXiTc7VFDO</addsrcrecordid><sourcetype>Institutional Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis</title><source>Lirias (KU Leuven Association)</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS)</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>van Tok, Melissa N ; Yeremenko, Nataliya G ; Teitsma, Christine A ; Kream, Barbara E ; Knaup, Véronique L ; Lories, Rik ; Baeten, Dominique L ; van Duivenvoorde, Leonie M</creator><contributor>Heymann, Dominique</contributor><creatorcontrib>van Tok, Melissa N ; Yeremenko, Nataliya G ; Teitsma, Christine A ; Kream, Barbara E ; Knaup, Véronique L ; Lories, Rik ; Baeten, Dominique L ; van Duivenvoorde, Leonie M ; Heymann, Dominique</creatorcontrib><description>Insulin like growth factor (IGF)-I can act on a variety of cells involved in cartilage and bone repair, yet IGF-I has not been studied extensively in the context of inflammatory arthritis. The objective of this study was to investigate whether IGF-I overexpression in the osteoblast lineage could lead to increased reparative or pathological bone formation in rheumatoid arthritis and/or spondyloarthritis respectively.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><language>eng</language><publisher>Public Library of Sciene</publisher><ispartof>PLoS One, 2016, Vol.11 (10)</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,776,780,4009,27839</link.rule.ids></links><search><contributor>Heymann, Dominique</contributor><creatorcontrib>van Tok, Melissa N</creatorcontrib><creatorcontrib>Yeremenko, Nataliya G</creatorcontrib><creatorcontrib>Teitsma, Christine A</creatorcontrib><creatorcontrib>Kream, Barbara E</creatorcontrib><creatorcontrib>Knaup, Véronique L</creatorcontrib><creatorcontrib>Lories, Rik</creatorcontrib><creatorcontrib>Baeten, Dominique L</creatorcontrib><creatorcontrib>van Duivenvoorde, Leonie M</creatorcontrib><title>Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis</title><title>PLoS One</title><description>Insulin like growth factor (IGF)-I can act on a variety of cells involved in cartilage and bone repair, yet IGF-I has not been studied extensively in the context of inflammatory arthritis. The objective of this study was to investigate whether IGF-I overexpression in the osteoblast lineage could lead to increased reparative or pathological bone formation in rheumatoid arthritis and/or spondyloarthritis respectively.</description><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>FZOIL</sourceid><recordid>eNqVyr0OgjAUQOHGaCL-vMPdHAwJtoA4qoiSGCYHN9LgNVaxNe0FfXwXB0edzhm-DvNmC8H9mAei-_V9NnDuGgSRSOLYY8dcu6ZW2t-rG8LWmiddIJMVGQs5pAYdFIYgtapFKPAJK6MRMmPvkpTRoDRsXg-06o6aZA1LSxerSLkR651l7XD86ZBNss1hvfNvTY1Ni7o8uYessJxxEUbxPFmU0TzhIRf_yOlvsqQXiTc7VFDO</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>van Tok, Melissa N</creator><creator>Yeremenko, Nataliya G</creator><creator>Teitsma, Christine A</creator><creator>Kream, Barbara E</creator><creator>Knaup, Véronique L</creator><creator>Lories, Rik</creator><creator>Baeten, Dominique L</creator><creator>van Duivenvoorde, Leonie M</creator><general>Public Library of Sciene</general><scope>FZOIL</scope></search><sort><creationdate>2016</creationdate><title>Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis</title><author>van Tok, Melissa N ; Yeremenko, Nataliya G ; Teitsma, Christine A ; Kream, Barbara E ; Knaup, Véronique L ; Lories, Rik ; Baeten, Dominique L ; van Duivenvoorde, Leonie M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kuleuven_dspace_123456789_5782423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Tok, Melissa N</creatorcontrib><creatorcontrib>Yeremenko, Nataliya G</creatorcontrib><creatorcontrib>Teitsma, Christine A</creatorcontrib><creatorcontrib>Kream, Barbara E</creatorcontrib><creatorcontrib>Knaup, Véronique L</creatorcontrib><creatorcontrib>Lories, Rik</creatorcontrib><creatorcontrib>Baeten, Dominique L</creatorcontrib><creatorcontrib>van Duivenvoorde, Leonie M</creatorcontrib><collection>Lirias (KU Leuven Association)</collection><jtitle>PLoS One</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Tok, Melissa N</au><au>Yeremenko, Nataliya G</au><au>Teitsma, Christine A</au><au>Kream, Barbara E</au><au>Knaup, Véronique L</au><au>Lories, Rik</au><au>Baeten, Dominique L</au><au>van Duivenvoorde, Leonie M</au><au>Heymann, Dominique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis</atitle><jtitle>PLoS One</jtitle><date>2016</date><risdate>2016</risdate><volume>11</volume><issue>10</issue><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Insulin like growth factor (IGF)-I can act on a variety of cells involved in cartilage and bone repair, yet IGF-I has not been studied extensively in the context of inflammatory arthritis. The objective of this study was to investigate whether IGF-I overexpression in the osteoblast lineage could lead to increased reparative or pathological bone formation in rheumatoid arthritis and/or spondyloarthritis respectively.</abstract><pub>Public Library of Sciene</pub><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PLoS One, 2016, Vol.11 (10)
issn 1932-6203
1932-6203
language eng
recordid cdi_kuleuven_dspace_123456789_578242
source Lirias (KU Leuven Association); DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry
title Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T08%3A25%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-kuleuven&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Insulin-Like%20Growth%20Factor%20I%20Does%20Not%20Drive%20New%20Bone%20Formation%20in%20Experimental%20Arthritis&rft.jtitle=PLoS%20One&rft.au=van%20Tok,%20Melissa%20N&rft.date=2016&rft.volume=11&rft.issue=10&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/&rft_dat=%3Ckuleuven%3E123456789_578242%3C/kuleuven%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true