Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis

Insulin like growth factor (IGF)-I can act on a variety of cells involved in cartilage and bone repair, yet IGF-I has not been studied extensively in the context of inflammatory arthritis. The objective of this study was to investigate whether IGF-I overexpression in the osteoblast lineage could lea...

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Veröffentlicht in:	PLoS One 2016, Vol.11 (10)
Hauptverfasser:	van Tok, Melissa N, Yeremenko, Nataliya G, Teitsma, Christine A, Kream, Barbara E, Knaup, Véronique L, Lories, Rik, Baeten, Dominique L, van Duivenvoorde, Leonie M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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Zusammenfassung:	Insulin like growth factor (IGF)-I can act on a variety of cells involved in cartilage and bone repair, yet IGF-I has not been studied extensively in the context of inflammatory arthritis. The objective of this study was to investigate whether IGF-I overexpression in the osteoblast lineage could lead to increased reparative or pathological bone formation in rheumatoid arthritis and/or spondyloarthritis respectively.
ISSN:	1932-6203 1932-6203