Noninvasive Imaging of Islet Transplants with 111In-Exendin-3 SPECT/CT

Noninvasive Imaging of Islet Transplants with 111In-Exendin-3 SPECT/CT

Islet transplantation is a promising treatment for type 1 diabetic patients. However, there is acute as well as chronic loss of islets after transplantation. A noninvasive imaging method that could monitor islet mass might help to improve transplantation outcomes. In this study, islets were visualiz...

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Veröffentlicht in:Journal of Nuclear Medicine 2016-05, Vol.57 (5), p.799-804
Hauptverfasser: van der Kroon, Inge, Andralojc, Karolina, Willekens, Stefanie, Bos, Desirée, Joosten, Lieke, Boerman, Otto C, Brom, Maarten, Gotthardt, Martin
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container_end_page 804
container_issue 5
container_start_page 799
container_title Journal of Nuclear Medicine
container_volume 57
creator van der Kroon, Inge
Andralojc, Karolina
Willekens, Stefanie
Bos, Desirée
Joosten, Lieke
Boerman, Otto C
Brom, Maarten
Gotthardt, Martin
description Islet transplantation is a promising treatment for type 1 diabetic patients. However, there is acute as well as chronic loss of islets after transplantation. A noninvasive imaging method that could monitor islet mass might help to improve transplantation outcomes. In this study, islets were visualized after transplantation in a rat model with a dedicated small-animal SPECT scanner by targeting the glucagonlike peptide-1 receptor (GLP-1R), specifically expressed on β-cells, with (111)In-labeled exendin-3.
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title Noninvasive Imaging of Islet Transplants with 111In-Exendin-3 SPECT/CT
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