Noninvasive Imaging of Islet Transplants with 111In-Exendin-3 SPECT/CT

Noninvasive Imaging of Islet Transplants with 111In-Exendin-3 SPECT/CT

Islet transplantation is a promising treatment for type 1 diabetic patients. However, there is acute as well as chronic loss of islets after transplantation. A noninvasive imaging method that could monitor islet mass might help to improve transplantation outcomes. In this study, islets were visualiz...

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Veröffentlicht in:Journal of Nuclear Medicine 2016-05, Vol.57 (5), p.799-804
Hauptverfasser: van der Kroon, Inge, Andralojc, Karolina, Willekens, Stefanie, Bos, Desirée, Joosten, Lieke, Boerman, Otto C, Brom, Maarten, Gotthardt, Martin
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Sprache:eng
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Zusammenfassung:Islet transplantation is a promising treatment for type 1 diabetic patients. However, there is acute as well as chronic loss of islets after transplantation. A noninvasive imaging method that could monitor islet mass might help to improve transplantation outcomes. In this study, islets were visualized after transplantation in a rat model with a dedicated small-animal SPECT scanner by targeting the glucagonlike peptide-1 receptor (GLP-1R), specifically expressed on β-cells, with (111)In-labeled exendin-3.
ISSN:0161-5505