Osteopontin, a Key Mediator Expressed by Senescent Pulmonary Vascular Cells in Pulmonary Hypertension

Osteopontin, a Key Mediator Expressed by Senescent Pulmonary Vascular Cells in Pulmonary Hypertension

Senescent pulmonary artery smooth muscle cells (PA-SMCs) may contribute to the pathogenesis of pulmonary hypertension by producing secreted factors. The aim of this study was to explore the role in pulmonary hypertension of extracellular matrix proteins released by senescent PA-SMCs.

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Veröffentlicht in:Arteriosclerosis, Thrombosis and Vascular Biology Thrombosis and Vascular Biology, 2016-09, Vol.36 (9), p.1879-90
Hauptverfasser: Saker, Mirna, Lipskaia, Larissa, Marcos, Elisabeth, Abid, Shariq, Parpaleix, Aurelien, Houssaini, Amal, Validire, Pierre, Girard, Philippe, Noureddine, Hiba, Boyer, Laurent, Vienney, Nora, Amsellem, Valerie, Marguerit, Laurent, Maitre, Bernard, Derumeaux, Geneviève, Dubois-Rande, Jean-Luc, Jourdan-Lesaux, Claude, Delcroix, Marion, Quarck, Rozenn, Adnot, Serge
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Sprache:eng
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Zusammenfassung:Senescent pulmonary artery smooth muscle cells (PA-SMCs) may contribute to the pathogenesis of pulmonary hypertension by producing secreted factors. The aim of this study was to explore the role in pulmonary hypertension of extracellular matrix proteins released by senescent PA-SMCs.
ISSN:1079-5642