Activity and safety of ceritinib in patients with ALK-rearranged non-small-cell lung cancer (ASCEND-1): updated results from the multicentre, open-label, phase 1 trial

Activity and safety of ceritinib in patients with ALK-rearranged non-small-cell lung cancer (ASCEND-1): updated results from the multicentre, open-label, phase 1 trial

ALK-rearranged non-small-cell lung cancer (NSCLC) is sensitive to ALK tyrosine kinase inhibitors (ALK inhibitors) such as crizotinib, but resistance invariably develops, often with progression in the brain. Ceritinib is a more potent ALK inhibitor than crizotinib in vitro, crosses the blood-brain ba...

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Veröffentlicht in:The Lancet Oncology 2016-04, Vol.17 (4), p.452-463
Hauptverfasser: Kim, Dong-Wan, Mehra, Ranee, Tan, Daniel S.W, Felip, Enriqueta, Chow, Laura Q.M, Camidge, D. Ross, Vansteenkiste, Johan, Sharma, Sunil, De Pas, Tommaso, Riely, Gregory J, Solomon, Benjamin J, Wolf, Jürgen, Thomas, Michael, Schuler, Martin, Liu, Geoffrey, Santoro, Armando, Sutradhar, Santosh, Li, Siyu, Szczudlo, Tomasz, Yovine, Alejandro, Shaw, Alice T
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Sprache:eng
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Zusammenfassung:ALK-rearranged non-small-cell lung cancer (NSCLC) is sensitive to ALK tyrosine kinase inhibitors (ALK inhibitors) such as crizotinib, but resistance invariably develops, often with progression in the brain. Ceritinib is a more potent ALK inhibitor than crizotinib in vitro, crosses the blood-brain barrier in vivo, and shows clinical responses in patients with crizotinib-resistant disease. We aimed to assess whole-body activity of ceritinib in both ALK inhibitor-pretreated and ALK inhibitor-naive patients with ALK-rearranged NSCLC.
ISSN:1470-2045