Effect of genetic background and postinfectious stress on visceral sensitivity in Citrobacter rodentium-infected mice

Effect of genetic background and postinfectious stress on visceral sensitivity in Citrobacter rodentium-infected mice

Infectious gastroenteritis is a major risk factor to develop postinfectious irritable bowel syndrome (PI-IBS). It remains unknown why only a subgroup of infected individuals develops PI-IBS. We hypothesize that immunogenetic predisposition is an important risk factor. Hence, we studied the effect of...

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Veröffentlicht in:Neurogastroenterology and Motility 2016-05, Vol.28 (5), p.647-658
Hauptverfasser: Mondelaers, Stéphanie, Theofanous, Stavroula, Florens, Morgane, Perna, Eluisa, Aguilera, Javier, Boeckxstaens, Guy, Wouters, Mira
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Sprache:eng
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Zusammenfassung:Infectious gastroenteritis is a major risk factor to develop postinfectious irritable bowel syndrome (PI-IBS). It remains unknown why only a subgroup of infected individuals develops PI-IBS. We hypothesize that immunogenetic predisposition is an important risk factor. Hence, we studied the effect of Citrobacter rodentium infection on visceral sensitivity in Th1-predominant C57BL/6 and Th2-predominant Balb/c mice.
ISSN:1350-1925