A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients

Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA damage and, if not repaired, cell death. Since base excision repair (BER) activity is specifi...

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Veröffentlicht in:	BMC Cancer 2015, Vol.15 (1), p.978
Hauptverfasser:	Seibold, Petra, Schmezer, Peter, Behrens, Sabine, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Q, Flesch-Janys, Dieter, Nevanlinna, Heli, Fagerholm, Rainer, Aittomäki, Kristiina, Blomqvist, Carl, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M, Lambrechts, Diether, Wildiers, Hans, Kristensen, Vessela, Alnæs, Grethe Grenaker, Nord, Silje, Borresen-Dale, Anne-Lise, Hooning, Maartje J, Hollestelle, Antoinette, Jager, Agnes, Seynaeve, Caroline, Li, Jingmei, Liu, Jianjun, Humphreys, Keith, Dunning, Alison M, Rhenius, Valerie, Shah, Mitul, Kabisch, Maria, Torres, Diana, Ulmer, Hans-Ulrich, Hamann, Ute, Schildkraut, Joellen M, Purrington, Kristen S, Couch, Fergus J, Hall, Per, Pharoah, Paul, Easton, Doug F, Schmidt, Marjanka K, Chang-Claude, Jenny, Popanda, Odilia
Format:	Artikel
Sprache:	eng
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Zusammenfassung:	Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA damage and, if not repaired, cell death. Since base excision repair (BER) activity is specific for oxidative DNA damage, we hypothesized that germline genetic variation in this pathway will affect breast cancer-specific survival depending on treatment.
ISSN:	1471-2407 1471-2407