Evidence that interactive effects of COMT and MTHFR moderate psychotic response to environmental stress

Evidence that interactive effects of COMT and MTHFR moderate psychotic response to environmental stress

A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahydrofolate reductase (MTHFR) C677T has been shown to differentially affect cognition in patients with schizophrenia and healthy controls; the effect of COMT Val158Met × MTHFR interaction on resilience t...

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Veröffentlicht in:Acta Psychiatrica Scandinavica 2012-03, Vol.125 (3), p.247-56
Hauptverfasser: Peerbooms, O, Rutten, B.P.F, Collip, D, Lardinois, M, Lataster, T, Thewissen, V, Rad, S. Mafi, Drukker, M, Kenis, G, van Os, J, Myin-Germeys, Inez, van Winkel, Ruud
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Sprache:eng
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Zusammenfassung:A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahydrofolate reductase (MTHFR) C677T has been shown to differentially affect cognition in patients with schizophrenia and healthy controls; the effect of COMT Val158Met × MTHFR interaction on resilience to stress in patients and controls remains to be examined.
ISSN:0001-690X