A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation

Genome-wide association studies (GWAS) have identified several loci associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis as a broad syndrome rather than within specific diagnostic categories.

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Veröffentlicht in:Biological Psychiatry 2014-03, Vol.75 (5), p.386-97
Hauptverfasser: Bramon, Elvira, Pirinen, Matti, Strange, Amy, Lin, Kuang, Freeman, Colin, Bellenguez, Céline, Su, Zhan, Band, Gavin, Pearson, Richard, Vukcevic, Damjan, Langford, Cordelia, Deloukas, Panos, Hunt, Sarah, Gray, Emma, Dronov, Serge, Potter, Simon C, Tashakkori-Ghanbaria, Avazeh, Edkins, Sarah, Bumpstead, Suzannah J, Arranz, Maria J, Bakker, Steven, Bender, Stephan, Bruggeman, Richard, Cahn, Wiepke, Chandler, David, Collier, David A, Crespo-Facorro, Benedicto, Dazzan, Paola, de Haan, Lieuwe, Di Forti, Marta, Dragović, Milan, Giegling, Ina, Hall, Jeremy, Iyegbe, Conrad, Jablensky, Assen, Kahn, René S, Kalaydjieva, Luba, Kravariti, Eugenia, Lawrie, Stephen, Linszen, Don H, Mata, Ignacio, McDonald, Colm, McIntosh, Andrew, Myin-Germeys, Inez, Ophoff, Roel A, Pariante, Carmine M, Paunio, Tiina, Picchioni, Marco, Ripke, Stephan, Rujescu, Dan, Sauer, Heinrich, Shaikh, Madiha, Sussmann, Jessika, Suvisaari, Jaana, Tosato, Sarah, Toulopoulou, Timothea, Van Os, Jim, Walshe, Muriel, Weisbrod, Matthias, Whalley, Heather, Wiersma, Durk, Blackwell, Jenefer M, Brown, Matthew A, Casas, Juan P, Corvin, Aiden, Duncanson, Audrey, Jankowski, Janusz A.Z, Markus, Hugh S, Mathew, Christopher G, Palmer, Colin N.A, Plomin, Robert, Rautanen, Anna, Sawcer, Stephen J, Trembath, Richard C, Wood, Nicholas W, Barroso, Ines, Peltonen, Leena, Lewis, Cathryn M, Murray, Robin M, Donnelly, Peter, Powell, John, Spencer, Chris C.A
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Sprache:eng
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Zusammenfassung:Genome-wide association studies (GWAS) have identified several loci associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis as a broad syndrome rather than within specific diagnostic categories.
ISSN:0006-3223