Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog

Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog

Two alternative syntheses of 2-oxaadamantan-5-amine, a novel analog of the clinically approved drug amantadine, are reported. The compound has been tested as an anti-influenza A virus agent and as an NMDA receptor antagonist. While the compound was not antivirally active, it displayed moderate activ...

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Veröffentlicht in:Tetrahedron Letters 2015-03, Vol.56 (10), p.1272-1275
Hauptverfasser: Leiva, Rosana, Gazzarrini, Sabrina, Esplugas, Roser, Moroni, Anna, Naesens, Lieve, Sureda, Francesc X, Vazquez, Santiago
Format: Artikel
Sprache:eng
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Zusammenfassung:Two alternative syntheses of 2-oxaadamantan-5-amine, a novel analog of the clinically approved drug amantadine, are reported. The compound has been tested as an anti-influenza A virus agent and as an NMDA receptor antagonist. While the compound was not antivirally active, it displayed moderate activity as an NMDA receptor antagonist.
ISSN:0040-4039