Cognitive Decline Preceding the Onset of Psychosis in Patients With 22q11.2 Deletion Syndrome

Cognitive Decline Preceding the Onset of Psychosis in Patients With 22q11.2 Deletion Syndrome

Patients with 22q11.2 deletion syndrome (22q11DS) have an elevated (25%) risk of developing schizophrenia. Recent reports have suggested that a subgroup of children with 22q11DS display a substantial decline in cognitive abilities starting at a young age.

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Veröffentlicht in:JAMA Psychiatry 2015-04, Vol.72 (4), p.377-85
Hauptverfasser: Vorstman, Jacob A.S, Breetvelt, Elemi J, Duijff, Sasja N, Eliez, Stephan, Schneider, Maude, Jalbrzikowski, Maria, Armando, Marco, Vicari, Stefano, Shashi, Vandana, Hooper, Stephen R, Chow, Eva W.C, Fung, Wai Lun Alan, Butcher, Nancy J, Young, Donald A, McDonald-McGinn, Donna M, Vogels, Annick, van Amelsvoort, Therese, Gothelf, Doron, Weinberger, Ronnie, Weizman, Abraham, Klaassen, Petra W.J, Koops, Sanne, Kates, Wendy R, Antshel, Kevin M, Simon, Tony J, Ousley, Opal Y, Swillen, Ann, Gur, Raquel E, Bearden, Carrie E, Kahn, René S, Bassett, Anne S, for the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome
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Sprache:eng
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Zusammenfassung:Patients with 22q11.2 deletion syndrome (22q11DS) have an elevated (25%) risk of developing schizophrenia. Recent reports have suggested that a subgroup of children with 22q11DS display a substantial decline in cognitive abilities starting at a young age.
ISSN:2168-622X