Dynamics of tumor hypoxia assessed by 18F-FAZA PET/CT in head and neck and lung cancer patients during chemoradiation: possible implications for radiotherapy treatment planning strategies

Dynamics of tumor hypoxia assessed by 18F-FAZA PET/CT in head and neck and lung cancer patients during chemoradiation: possible implications for radiotherapy treatment planning strategies

To define the optimal time point for the integration of hypoxia (18)F-FAZA-PET/CT information into radiotherapy treatment planning to benefit from hypoxia modification or dose escalation treatment. Therefore, we performed a prospective cohort study, using serial hypoxic imaging ((18)F-FAZA-PET/CT) p...

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Veröffentlicht in:Radiotherapy and Oncology 2014-11, Vol.113 (2), p.198-203
Hauptverfasser: Bollineni, Vikram R, Koole, Michel, Pruim, Jan, Brouwer, Charlotte L, Wiegman, Erwin M, Groen, Harry J.M, Vlasman, Renske, Halmos, Gyorgy B, Oosting, Sjoukje F, Langendijk, Johannes A, Widder, Joachim, Steenbakkers, Roel J.H.M
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Sprache:eng
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Zusammenfassung:To define the optimal time point for the integration of hypoxia (18)F-FAZA-PET/CT information into radiotherapy treatment planning to benefit from hypoxia modification or dose escalation treatment. Therefore, we performed a prospective cohort study, using serial hypoxic imaging ((18)F-FAZA-PET/CT) prior to and at several time-points during (chemo)radiotherapy (CHRT) in six head and neck squamous cell (HNSCC) and six non-small cell lung cancer (NSCLC) patients.
ISSN:0167-8140