Regulation of High-Density Lipoprotein on Hematopoietic Stem/Progenitor Cells in Atherosclerosis Requires Scavenger Receptor Type BI Expression

Regulation of High-Density Lipoprotein on Hematopoietic Stem/Progenitor Cells in Atherosclerosis Requires Scavenger Receptor Type BI Expression

Recently, we demonstrated that scavenger receptor type BI (SR-BI), a high-density lipoprotein (HDL) receptor, was expressed on murine hematopoietic stem/progenitor cells (HSPC) and infusion of reconstituted HDL and purified human apolipoprotein A-I (apoA-I) suppressed HSPC proliferation. We hypothes...

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Veröffentlicht in:Arteriosclerosis, Thrombosis and Vascular Biology Thrombosis and Vascular Biology, 2014-09, Vol.34 (9), p.1900-9
Hauptverfasser: Gao, Mingming, Zhao, Dongxing, Schouteden, Sarah, Sorci-Thomas, Mary G, Van Veldhoven, Paul P, Eggermont, Kristel, Liu, George, Verfaillie, Catherine, Feng, Yingmei
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Sprache:eng
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Zusammenfassung:Recently, we demonstrated that scavenger receptor type BI (SR-BI), a high-density lipoprotein (HDL) receptor, was expressed on murine hematopoietic stem/progenitor cells (HSPC) and infusion of reconstituted HDL and purified human apolipoprotein A-I (apoA-I) suppressed HSPC proliferation. We hypothesized that SR-B1 expression is required for the observed antiproliferative effects of HDL on HSPC.
ISSN:1079-5642