First example of a continuous flow carbonylation reaction using aryl formates as CO precursors

First example of a continuous flow carbonylation reaction using aryl formates as CO precursors

© 2014 Akadémiai Kiadó. The first continuous flow carbonylation reaction using aryl formates as CO precursor is reported. The reaction is practical, scalable and high yielding. The use of a flow protocol safely allows expanding the scope to activated chlorides, nitrogen heterocycles and to the selec...

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Veröffentlicht in:Journal of Flow Chemistry 2014, Vol.4 (3), p.105-109
Hauptverfasser: Alonso, Nerea, Muñoz, Juan de M, Egle, Brecht, Vrijdag, Johannes L, De Borggraeve, Wim M, de la Hoz, Antonio, Díaz-Ortiz, Angel, Alcázar, Jesús
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Sprache:eng
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Zusammenfassung:© 2014 Akadémiai Kiadó. The first continuous flow carbonylation reaction using aryl formates as CO precursor is reported. The reaction is practical, scalable and high yielding. The use of a flow protocol safely allows expanding the scope to activated chlorides, nitrogen heterocycles and to the selective introduction of an ester group in dihalo-derivatives. Further selective reduction of the ester formed to an aldehyde in flow is also described.
ISSN:2062-249X