Oligonucleotides with 2,6-diaiminopurine base replacing for adenine: Synthesis and properties

Oligonucleotides with 2,6-diaiminopurine base replacing for adenine: Synthesis and properties

Synthesis of three nucleoside building blocks with a benzoyl protected diaminopurine (DAP) base and their incorporation at different positions of DNA, RNA and hexitol oligomers (HNA) have been accomplished. DNA hairpins with a DAP substituted for one (or more) adenine in the loop structure were not...

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Veröffentlicht in:Nucleosides & Nucleotides 1999, Vol.18 (6), p.1429-1431
Hauptverfasser: Boudou, V, Rothenbacher, K, Van Aerschot, Arthur, Herdewijn, Piet
Format: Artikel
Sprache:eng
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Zusammenfassung:Synthesis of three nucleoside building blocks with a benzoyl protected diaminopurine (DAP) base and their incorporation at different positions of DNA, RNA and hexitol oligomers (HNA) have been accomplished. DNA hairpins with a DAP substituted for one (or more) adenine in the loop structure were not found to be more stable. But the stability of RNA-hexitol as well as hexitol-hexitol duplexes improved when the adenine base was replaced with DAP.
ISSN:0732-8311