Keratin 19: a key role player in the invasion of human hepatocellular carcinomas

Keratin 19: a key role player in the invasion of human hepatocellular carcinomas

Keratin (K)19, a biliary/hepatic progenitor cell (HPC) marker, is expressed in a subset of hepatocellular carcinomas (HCC) with poor prognosis. The underlying mechanisms driving this phenotype of K19-positive HCC remain elusive.

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Veröffentlicht in:Gut 2014-04, Vol.63 (4), p.674-685
Hauptverfasser: Govaere, Olivier, Komuta, M.Ina, Berkers, Joost, Spee, Bart, Janssen, Carl, de Luca, Francesca, Katoonizadeh, Aezam, Wouters, Jasper, van Kempen, Léon C, Durnez, Anne, Verslype, Chris, De Kock, Joery, Rogiers, Vera, van Grunsven, Leo A, Topal, Baki, Pirenne, Jacques, Vankelecom, Hugo, Nevens, Frederik, van den Oord, Joost, Pinzani, Massimo, Roskams, Tania
Format: Artikel
Sprache:eng
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Zusammenfassung:Keratin (K)19, a biliary/hepatic progenitor cell (HPC) marker, is expressed in a subset of hepatocellular carcinomas (HCC) with poor prognosis. The underlying mechanisms driving this phenotype of K19-positive HCC remain elusive.
ISSN:0017-5749