Simple approach to the synthesis of 3-fluoro pyrazolo[1,5-a]pyrimidine analogues

Simple approach to the synthesis of 3-fluoro pyrazolo[1,5-a]pyrimidine analogues

A simple method for the synthesis of novel 3-fluoro pyrazolo[1,5-a] pyrimidine analogues has been developed starting from fluoro acetonitrile and benzoyl chloride. The desired compounds are synthesized from a 3-amino-4-fluoro pyrazole intermediate. The versatility of the approach was demonstrated by...

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Veröffentlicht in:Tetrahedron Letters 2013, Vol.54 (21), p.2612-2614
Hauptverfasser: Belabed, Hassen, Mammoliti, Oscar, Van Lommen, Guy, Herdewijn, Piet
Format: Artikel
Sprache:eng
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Zusammenfassung:A simple method for the synthesis of novel 3-fluoro pyrazolo[1,5-a] pyrimidine analogues has been developed starting from fluoro acetonitrile and benzoyl chloride. The desired compounds are synthesized from a 3-amino-4-fluoro pyrazole intermediate. The versatility of the approach was demonstrated by the synthesis of a small library of pyrazolo[1,5-a]pyrimidine. © 2013 Elsevier Ltd. All rights reserved.
ISSN:0040-4039