Common Variants at VRK2 and TCF4 Conferring Risk of Schizophrenia

Common Variants at VRK2 and TCF4 Conferring Risk of Schizophrenia

Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association (GWA) study and meta-analysis (totalling 7,946 cases and 19,036 controls) by examining an expand...

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Veröffentlicht in:Human Molecular Genetics 2011-10, Vol.20 (20), p.4076-4081
Hauptverfasser: Steinberg, Stacy, de Jong, Simone, Irish Schizophrenia Genomics Consortium, Andreassen, Ole A, Werge, Thomas, Børglum, Anders D, Mors, Ole, Mortensen, Preben B, Gustafsson, Omar, Costas, Javier, Pietiläinen, Olli P.H, Demontis, Ditte, Papiol, Sergi, Huttenlocher, Johanna, Mattheisen, Manuel, Breuer, René, Vassos, Evangelos, Giegling, Ina, Fraser, Gillian, Walker, Nicholas, Tuulio-Henriksson, Annamari, Suvisaari, Jaana, Lönnqvist, Jouko, Paunio, Tiina, Agartz, Ingrid, Melle, Ingrid, Djurovic, Srdjan, Strengman, Eric, GROUP, Jürgens, Gesche, Glenthøj, Birte, Terenius, Lars, Hougaard, David M, Orntoft, Torben, Wiuf, Carsten, Didriksen, Michael, Hollegaard, Mads V, Nordentoft, Merete, van Winkel, Ruud, Kenis, Gunter, Abramova, Lilia, Kaleda, Vasily, Arrojo, Manuel, Sanjuán, Julio, Arango, Celso, Sperling, Swetlana, Rossner, Moritz, Ribolsi, Michele, Magni, Valentina, Siracusano, Alberto, Christiansen, Claus, Kiemeney, Lambertus A, Veldink, Jan, van den Berg, Leonard, Ingason, Andres, Muglia, Pierandrea, Murray, Robin, Nöthen, Markus M, Sigurdsson, Engilbert, Petursson, Hannes, Thorsteinsdottir, Unnur, Kong, Augustine, Rubino, I. Alex, De Hert, Marc, Réthelyi, János M, Bitter, István, Jönsson, Erik G, Golimbet, Vera, Carracedo, Angel, Ehrenreich, Hannelore, Craddock, Nick, Owen, Michael J, O'Donovan, Michael C, Wellcome Trust Case Control Consortium, Ruggeri, Mirella, Tosato, Sarah, Peltonen, Leena, Ophoff, Roel A, Collier, David A, St Clair, David, Rietschel, Marcella, Cichon, Sven, Stefansson, Hreinn, Rujescu, Dan, Stefansson, Kari
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Sprache:eng
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Zusammenfassung:Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association (GWA) study and meta-analysis (totalling 7,946 cases and 19,036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10,260 cases and 23,500 controls). In addition to previously-reported alleles in the major histocompatibility complex (MHC) region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) (OR = 1.09, P = 1.9 x 10(-9)), and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously-described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 x 10(-9)).
ISSN:0964-6906