Omega Loops of Proteins in Homo Sapiens: Role in Diseases

Omega(Ω-) loops are non-regular secondary structures formed by poly-peptide chains, that are characterized by loop-shaped structures in three-dimensional space. Omega loops have been found to involve in protein stability, folding and function. The study on the structural geometry and prediction of Ω-loops have been carried out by many researchers [1], [2], [3], however, analysis on the involvement of these loops in disease-related interactions of Homo sapiens is significantly rare. In this study, Ω-loops that are involved in the interactions, causing potential diseases in Homo sapiens have been analyzed, at the level of their structures, functions and their involvement in diseases. The information on the understanding of the disease-causing interactions and other properties of Ω-loops could be used in potential drug design against these diseases.