Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson's disease discerned with microSPECT and quantitative MRI

Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson's disease discerned with microSPECT and quantitative MRI

In the present study, we aimed to evaluate the impact of neurodegeneration of the nigrostriatal tract in a rodent model of Parkinson's disease on the different MR contrasts (T(2), T(1), CBF and CBV) measured in the striatum.

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Veröffentlicht in:Magnetic Resonance Materials in Biology, Physics and Medicine Physics and Medicine, 2010-04, Vol.23 (2), p.65-75
Hauptverfasser: Van Camp, Nadja, Vreys, Ruth, Van Laere, Koen, Lauwers, Erwin, Beque, Dirk, Verhoye, Marleen, Casteels, Cindy, Verbruggen, Alfons, Debyser, Zeger, Mortelmans, Luc, Sijbers, Jan, Nuyts, Johan, Baekelandt, Veerle, Van der Linden, Annemie
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Sprache:eng
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Zusammenfassung:In the present study, we aimed to evaluate the impact of neurodegeneration of the nigrostriatal tract in a rodent model of Parkinson's disease on the different MR contrasts (T(2), T(1), CBF and CBV) measured in the striatum.
ISSN:0968-5243