Labelling and biological evaluation of [C-11]methoxy-Sch225336: a radioligand for the cannabinoide-type 2 receptor

Introduction: The cannabinoid type 2 receptor (CB2 receptor) is part of the endocannabinoid system and has been suggested as mediator of a number of central and peripheral inflammatory processes. In the present Study, we have synthesized N-[(Is)-I-[4-[[4-methoxy-2-[(4-[C-11] methoxyphenyl)sulfonyl)-phenyl]sulfonyl] phenyl]ethyl]methanesulfonamide ([C-11]methoxy-Sch225336) and evaluated this new tracer agent as a potential positron emission tomography radioligand for the in vivo visualization of CB2 receptors.