Cross hybridization between "six-membered" nucleic acids: RNA as a universal information system

Cross hybridization between "six-membered" nucleic acids: RNA as a universal information system

Within the polyA:polyT recognition system, cross-pairing between several nucleic acids with a phosphorylated six-membered carbohydrate (mimic) as repeating unit in the backbone structure has been observed. All investigated nucleic acids (except for beta-homo-DNA) hybridize with RNA, leaving RNA as a...

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Veröffentlicht in:Organic letters 2001-12, Vol.3 (26), p.4129-4132
Hauptverfasser: Kerremans, Lucien, Schepers, Guy, Rozenski, Jef, Busson, Roger, Van Aerschot, Arthur, Herdewijn, Piet
Format: Artikel
Sprache:eng
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Zusammenfassung:Within the polyA:polyT recognition system, cross-pairing between several nucleic acids with a phosphorylated six-membered carbohydrate (mimic) as repeating unit in the backbone structure has been observed. All investigated nucleic acids (except for beta-homo-DNA) hybridize with RNA, leaving RNA as a versatile biopolymer for informational transfer. [reaction: see text]
ISSN:1523-7060