Identification of novel erythromycin derivatives in mother liquor concentrates of Streptomyces erythraeus

Identification of novel erythromycin derivatives in mother liquor concentrates of Streptomyces erythraeus

The identification of five novel compounds, pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-N-demethylerythromycin A-6,9-hemiketal, 5-O-beta-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyces...

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Veröffentlicht in:The Journal of antibiotics 1987-01, Vol.40 (1), p.1-6
Hauptverfasser: Kibwage, I.O, Janssen, Gerardus, Busson, Roger, Hoogmartens, Jos, Vanderhaeghe, Hubert, Verbist, Ludo
Format: Artikel
Sprache:eng
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Zusammenfassung:The identification of five novel compounds, pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-N-demethylerythromycin A-6,9-hemiketal, 5-O-beta-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyces erythraeus is described. The pseudo-erythromycin derivatives are characterized by a 12-membered macrocyclic ring as a result of C13---C11 trans-lactonization. The five compounds have very little antimicrobial activity.
ISSN:0021-8820