Immunomodulatory Effects by Bifidobacterium longum KACC 91563 in Mouse Splenocytes and Macrophages
The present study evaluates the immunomodulatory effect of Bifidobacterium longum KACC 91563 in murine primary splenocytes and macrophages. B. longum KACC 91563 regulated Tand B-cell proliferation and inhibited the Th1 (IL-2, IFN-γ)/Th2 (IL-4, IL-10) cytokine imbalance and immune cytokine production...
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| Veröffentlicht in: | Journal of microbiology and biotechnology 2019-11, Vol.29 (11), p.1739-1744 |
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| container_issue | 11 |
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| container_title | Journal of microbiology and biotechnology |
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| creator | Choi, Mijoo Lee, Yunjung Lee, Na-Kyoung Bae, Chun Ho Park, Dae Chul Paik, Hyun-Dong Park, Eunju |
| description | The present study evaluates the immunomodulatory effect of Bifidobacterium longum KACC 91563 in murine primary splenocytes and macrophages. B. longum KACC 91563 regulated Tand B-cell proliferation and inhibited the Th1 (IL-2, IFN-γ)/Th2 (IL-4, IL-10) cytokine imbalance and immune cytokine production. Moreover, immunoglobulin E (IgE) levels were significantly lower after treatment with B. longum KACC 91563. These findings suggest that B. longum KACC 91563 could modulate the systemic immune system toward both IgE production and regulation of the Th1/Th2 balance. |
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B. longum KACC 91563 regulated Tand B-cell proliferation and inhibited the Th1 (IL-2, IFN-γ)/Th2 (IL-4, IL-10) cytokine imbalance and immune cytokine production. Moreover, immunoglobulin E (IgE) levels were significantly lower after treatment with B. longum KACC 91563. 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| ispartof | Journal of microbiology and biotechnology, 2019-11, Vol.29 (11), p.1739-1744 |
| issn | 1017-7825 1738-8872 |
| language | kor |
| recordid | cdi_kisti_ndsl_JAKO201907750244302 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Bifidobacterium longum KACC 91563 cytokine immunomodulatory effect Th1/Th2 balance |
| title | Immunomodulatory Effects by Bifidobacterium longum KACC 91563 in Mouse Splenocytes and Macrophages |
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