Immunomodulatory Effects by Bifidobacterium longum KACC 91563 in Mouse Splenocytes and Macrophages

Immunomodulatory Effects by Bifidobacterium longum KACC 91563 in Mouse Splenocytes and Macrophages

The present study evaluates the immunomodulatory effect of Bifidobacterium longum KACC 91563 in murine primary splenocytes and macrophages. B. longum KACC 91563 regulated Tand B-cell proliferation and inhibited the Th1 (IL-2, IFN-γ)/Th2 (IL-4, IL-10) cytokine imbalance and immune cytokine production...

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Veröffentlicht in:Journal of microbiology and biotechnology 2019-11, Vol.29 (11), p.1739-1744
Hauptverfasser: Choi, Mijoo, Lee, Yunjung, Lee, Na-Kyoung, Bae, Chun Ho, Park, Dae Chul, Paik, Hyun-Dong, Park, Eunju
Format: Artikel
Sprache:kor
Schlagworte:
Bifidobacterium longum KACC 91563
cytokine
immunomodulatory effect
Th1/Th2 balance
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Zusammenfassung:The present study evaluates the immunomodulatory effect of Bifidobacterium longum KACC 91563 in murine primary splenocytes and macrophages. B. longum KACC 91563 regulated Tand B-cell proliferation and inhibited the Th1 (IL-2, IFN-γ)/Th2 (IL-4, IL-10) cytokine imbalance and immune cytokine production. Moreover, immunoglobulin E (IgE) levels were significantly lower after treatment with B. longum KACC 91563. These findings suggest that B. longum KACC 91563 could modulate the systemic immune system toward both IgE production and regulation of the Th1/Th2 balance.
ISSN:1017-7825
1738-8872