Penidioxolanes A and B, 1,3-Dioxolane Containing Azaphilone Derivatives from Marine-derived Penicillium sp. KCB12C078

Penidioxolanes A and B, 1,3-Dioxolane Containing Azaphilone Derivatives from Marine-derived Penicillium sp. KCB12C078

Two new azaphilone derivatives containing 1,3-dioxolane moiety, penidioxolanes A (1) and B (2), were isolated from marine-derived fungus Penicillium sp. KCB12C078, together with four known compounds (3-6) by chemical investigation. Compounds 1 - 6 were isolated by combination of silica gel, ODS colu...

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Veröffentlicht in:Natural product sciences 2015, Vol.21 (4), p.231-236
Hauptverfasser: Kim, Seung Min, Son, Sangkeun, Kim, Jong Won, Jeon, Eun Soo, Ko, Sung-Kyun, Ryoo, In-Ja, Shin, Kee-Sun, Hirota, Hiroshi, Takahashi, Shunji, Osada, Hiroyuki, Jang, Jae-Hyuk, Ahn, Jong Seog
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Sprache:kor
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Zusammenfassung:Two new azaphilone derivatives containing 1,3-dioxolane moiety, penidioxolanes A (1) and B (2), were isolated from marine-derived fungus Penicillium sp. KCB12C078, together with four known compounds (3-6) by chemical investigation. Compounds 1 - 6 were isolated by combination of silica gel, ODS column chromatography and preparative HPLC. Their structures were determined by analysis of spectroscopic data including 1D-, 2D-NMR, and MS techniques. The isolates were evaluated against cancer cell growth inhibition effects and antimicrobial activity.
ISSN:1226-3907