Estimation of Leucine Aminopeptidase and 5-Nucleotidase Increases Alpha-Fetoprotein Sensitivity in Human Hepatocellular Carcinoma Cases

Estimation of Leucine Aminopeptidase and 5-Nucleotidase Increases Alpha-Fetoprotein Sensitivity in Human Hepatocellular Carcinoma Cases

Purpose: To find parameters that can increase alpha-fetoprotein (AFP) sensitivity and so help in accurate diagnosis and rapid management of hepatocullular carcinoma (HCC), as AFP has limited utility of distinguishing HCC from benign hepatic disorders for its high false-positive and false negative ra...

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Veröffentlicht in:Asian Pacific journal of cancer prevention : APJCP 2015, Vol.16 (3), p.959-963
Hauptverfasser: Abouzied, Mekky Mohammed, Eltahir, Heba M, Fawzy, Michael Atef, Abdel-Hamid, Nabil Mohie, Gerges, Amany Saber, El-Ibiari, Hesham Mohmoud, Nazmy, Maiiada Hassan
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Zusammenfassung:Purpose: To find parameters that can increase alpha-fetoprotein (AFP) sensitivity and so help in accurate diagnosis and rapid management of hepatocullular carcinoma (HCC), as AFP has limited utility of distinguishing HCC from benign hepatic disorders for its high false-positive and false negative rates. Materials and Methods: Serum levels of AFP, 5'-nucleotidase enzyme activity (5-NU) and leucine aminopeptidase enzyme (LAP) activity were measured in 40 individuals. Results: LAP and 5'NU were elevated in HCC at p
ISSN:1513-7368
2476-762X