Possible Relation between the NOS3 Gene GLU298ASP Polymorphism and Bladder Cancer in Turkey

Possible Relation between the NOS3 Gene GLU298ASP Polymorphism and Bladder Cancer in Turkey

Endothelial nitric oxide synthase (eNOS), encoded by the NOS3 gene, has been suggested to play an important role in uncontrolled cell growth in several cancer types. The objective of this study was to evaluate the role of the NOS3 Glu298Asp polymorphism in bladder cancer susceptibility in a Turkish...

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Veröffentlicht in:Asian Pacific journal of cancer prevention : APJCP 2013, Vol.14 (2), p.665-668
Hauptverfasser: Verim, Levent, Toptas, Bahar, Ozkan, Nazli Ezgi, Cacina, Canan, Turan, Saime, Korkmaz, Gurbet, Yaylim, Ilhan
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Sprache:kor
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Zusammenfassung:Endothelial nitric oxide synthase (eNOS), encoded by the NOS3 gene, has been suggested to play an important role in uncontrolled cell growth in several cancer types. The objective of this study was to evaluate the role of the NOS3 Glu298Asp polymorphism in bladder cancer susceptibility in a Turkish population. We determined the genotypes of 66 bladder cancer cases and 88 healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism analysis. A significant association for NOS3 Glu298Asp heterozygotes genotypes and T allele were found between healthy controls and bladder cancer, respectively (p
ISSN:1513-7368
2476-762X