오디와 누에 섭취가 rats의 저항성 운동에 따른 androgen receptor mRNA와 myogenic regulatory factors의 발현에 미치는 영향

he purpose of this study is to investigate the effects of supplementation of mulberry powder, mulberry extract and silkworm powder during the 8 weeks of resistance exercise on Androgen receptor (AR) mRNA and Myogenic regulatory factors (MRFs) expression of rats muscle. Fifty males, Sprague-Dawley rat, were randomly divided into 5 groups: CON(control group, n = 10), REG (resistance exercise group, n = 10), MP REG (mulberry powder intake and resistance exercise group, n = 10), ME REG (mulberry extract intake and resistance exercise group, n = 10) and SP REG(silkworm powder intake and resistance exercise group, n = 10). After climbing the ladder without weights during the 1 week of adaptation period, the rats in the resistance exercise group were trained to climb a 0.98-m vertical (80 degree incline) ladder with weights in their tail during 7 weeks (10 times each day, 2 days per week). After exercise, the skeletal muscle was extracted from the flexor hallucis longus. After separating the total ribonucleic acid (RNA) of each group, quantitative polymerase chain reaction was used to analyze RNA quantitatively. AR mRNA and MRFs expression revealed that all of the treated groups had significantly difference. AR mRNA expression increased in ME REG 6.24 ± 1.85 and SP REG 9.68 ± 0.28 fold compared to CON. Myod mRNA expression increased in MP REG 6.04 ± 0.47, ME REG 4.31 ± 1.58 and SP REG 8.11 ± 0.57 fold compared to CON. And myogenin mRNA expression increased in MP REG 4.11 ± 0.42, ME REG 4.12 ± 0.45 and SP REG 6.50 ± 0.61 fold compared to CON. In conclusion, during the resistance exercise, providing mulberry and silkworm gives positive effect on AR mRNA and MRFs expression increase.