Comparison of D-[ 18 F]FMAU and L-[ 18 F]FMAU as PET Imaging Agents for HSV1-TK Gene Expression

D-[$^{18}F$]FMAU and L-[$^{18}F$]FMAU are F-18 labeled nucleoside analogue which have been efficiently synthesized in order to be a PET imaging probe. D-[$^{18}F$]FMAU and L-[$^{18}F$]FMAU were compared as PET imaging agents using HSV1-TK gene expressing tumor-bearing mice. Their cellular uptake pro...

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Veröffentlicht in:Bulletin of the Korean Chemical Society 2010, Vol.31 (11), p.3309-3312
Hauptverfasser: Moon, Byung-Seok, Jo, Nam-Hyun, Lee, Kyo-Chul, El-Gamal, Mohammed I, An, Gwang-Il, Hong, Su-Hee, Choi, Tae-Hyun, Choi, Won-Kyoung, Park, Jin-Hun, Cho, Jung-Hyuck, Cheon, Gi-Jeong, Oh, Chang-Hyun
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Sprache:kor
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Zusammenfassung:D-[$^{18}F$]FMAU and L-[$^{18}F$]FMAU are F-18 labeled nucleoside analogue which have been efficiently synthesized in order to be a PET imaging probe. D-[$^{18}F$]FMAU and L-[$^{18}F$]FMAU were compared as PET imaging agents using HSV1-TK gene expressing tumor-bearing mice. Their cellular uptake profiles were also compared using MCA and MCA-TK cell lines. D-[$^{18}F$]FMAU demonstrated higher cellular uptake and higher accumulation in MCA-TK tumor regions than L-[$^{18}F$]FMAU. On the other hand, L-[$^{18}F$]FMAU showed higher MCA-TK/MCA ratio of %ID/g than that of D-[$^{18}F$]FMAU. L-[$^{18}F$]FMAU can be utilized as a good candidate for HSV1-TK PET imaging. It can be used for antiviral drug evaluation.
ISSN:0253-2964
1229-5949