Farnesyl Protein Transferase Inhibitory Components of Lithospermum erythrorhizon

The methanolic extract of the roots of Lithospermum erythrorhizon (Boraginaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of three naphthoquinone compounds, as inhibitors of...

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Veröffentlicht in:	Natural product sciences 2007, Vol.13 (4), p.328-331
Hauptverfasser:	Kim, Seong-Jin, Kwon, Byoung-Mog, Kim, Sung-Hoon, Baek, Nam-In, Yang, Jae-Heon, Lee, Jeong-Joo, Lee, Sa-Im, Kwon, Young-Ee, Park, Hee-Wook, Lee, Jae-Hyeok, Park, Jeong-Suk, Kim, Dae-Keun
Format:	Artikel
Sprache:	kor
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Zusammenfassung:	The methanolic extract of the roots of Lithospermum erythrorhizon (Boraginaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of three naphthoquinone compounds, as inhibitors of FPTase. These compounds inhibited the FPTase activity in a dose-dependent manner.
ISSN:	1226-3907