Boronated Porphyrins and Chlorins as Potential Anticancer Drugs

Analyzed are recent advances in design of novel boronared conjugates of synthetic and natural porphyrins and chlorins. These compounds showed high efficacy as cytotoxic agents for tumor cells in culture and as phototoxins in photodynamic therapy of tumor xenografts. Thus, boronated porphyrins and ch...

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Veröffentlicht in:Bulletin of the Korean Chemical Society 2007, Vol.28 (11), p.1910-1916
Hauptverfasser: Ol'shevskaya, Valentina A, Zaytsev, Andrey V, Savchenko, Arina N, Shtil, Alexander A, Cheong, Chan-Seong, Kalinin, Valery N
Format: Artikel
Sprache:kor
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Zusammenfassung:Analyzed are recent advances in design of novel boronared conjugates of synthetic and natural porphyrins and chlorins. These compounds showed high efficacy as cytotoxic agents for tumor cells in culture and as phototoxins in photodynamic therapy of tumor xenografts. Thus, boronated porphyrins and chlorins emerge as promising class of anticancer agents with potentially multiple advantages: the chemotherapeutic drugs alone and photo- and radiosensitizers in binary treatments.
ISSN:0253-2964
1229-5949