New Cytotoxic Sulfated Saponins from the Starfish Certonardoa semiregularis
Two new sulfated saponins designated as certonardosides P$_{2}$ and I$_{3}$ (1 and 2) were isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis. Compounds 1 and 2 were tested for...
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| Veröffentlicht in: | Archives of pharmacal research 2005, Vol.28 (3), p.285-289 |
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| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | kor |
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| Zusammenfassung: | Two new sulfated saponins designated as certonardosides P$_{2}$ and I$_{3}$ (1 and 2) were isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis. Compounds 1 and 2 were tested for cytotoxicity against five human tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15), and compound 1 displayed significant cytotoxicity against the SK-MEL-2 skin cancer cell. |
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| ISSN: | 0253-6269 1976-3786 |