Synthesis and $PGE_2$ Inhibitory Activity of 5,7-Dihydroxyflavones and Their Ο-Methylated Flavone Analogs
5,7-Dihydroxyflavones and their Ο-methylated flavone analogs were prepared and evaluated their anti-inflammatory activity to decipher the structure-activity relationships. Most of the analogs were achieved from 2,4,6-trihydroxyacetophenone in 4 steps. 5,7-Dihydroxy-4 -methoxyflavone (4c) and 7-hydro...
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Veröffentlicht in: | Archives of pharmacal research 2003, Vol.26 (5), p.345-350 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | kor |
Online-Zugang: | Volltext |
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Zusammenfassung: | 5,7-Dihydroxyflavones and their Ο-methylated flavone analogs were prepared and evaluated their anti-inflammatory activity to decipher the structure-activity relationships. Most of the analogs were achieved from 2,4,6-trihydroxyacetophenone in 4 steps. 5,7-Dihydroxy-4 -methoxyflavone (4c) and 7-hydroxy-4 ,5-dimethoxyflavone(6c) were prepared following a different synthetic pathway. Among the synthetic flavones tested, 5-hydroxy-7-methoxyflavone analogs (3a-3e) showed moderate inhibitory activities of $PGE_2$ production from LPS-induced RAW 264.7 cells. |
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ISSN: | 0253-6269 1976-3786 |