아졸을 포함하는 신규 세파로스포린 유도체의 합성 및 항균력

아졸을 포함하는 신규 세파로스포린 유도체의 합성 및 항균력

9 New cephalosporin derivatives were synthesized and screened for antibacterial activities against various bacteria. (6R,7R) -7$\beta$-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(fluoromethoxyimino)acetamido]-3-[(2-hydroxycarbamoyl)-s-triazolo[1,5-a]-pyrimidin-7-yl]thiomethyl]-3-cephem-4-carboxylic ac...

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Veröffentlicht in:Yaghag-hoi-ji 2000-08, Vol.44 (4), p.318-324
Hauptverfasser: 임중인(Joong In Lim), 신현태(Hyun Tae Shin), 조종환(Chong Hwan Cho), 양재성(Jae Seong Yang), 윤석균(Suk Kyoon Yoon), 김원배(Won Bae Kim), 장민선(Min Sun Chang), 최성학(Seong Hak Choi), 임원빈(Weon Bin Im), 이재걸(Jae Keon Rhee)
Format: Artikel
Sprache:kor
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Zusammenfassung:9 New cephalosporin derivatives were synthesized and screened for antibacterial activities against various bacteria. (6R,7R) -7$\beta$-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(fluoromethoxyimino)acetamido]-3-[(2-hydroxycarbamoyl)-s-triazolo[1,5-a]-pyrimidin-7-yl]thiomethyl]-3-cephem-4-carboxylic acid sodium salt (compound 3) showed 2 fold enhanced in vitro activity against P. aerurginosa, compared to ceftazidime.
ISSN:0377-9556
2383-9457