언어영역의 기능적 자기공명영상

Purpose : To evaluate the usefulness of functional MR imaging (fMRI) for language mapping and determination of language lateralization. Materials and Methods : Functional maps of the language area were obtained during word generation tasks and decision task in ten volunteers (7 right handed, 3 left-handed). MR examinations were performed at 1.5T scanner with EPI BOLD technique. Each task consisted of three resting periods and two activation periods with each period of 30 seconds. Total acquisition time was 162 sec. SPM program was used for the postprocessing of images. Statistical comparisons were performed by using t-statistics on a pixel-by- pixel basis after global normalization by ANCOVA. Activation areas were topographically analyzed (p>0.001) and activated pixels in each hemisphere were compared quantitatively by lateralization index. Results : Significant activation signals were demonstrated in 9 of 10 volunteers. Activation signals were found in the premotor and motor cortices, the inferior frontal, inferior parietal, and mid-temporal lobes during stimulation tasks. In the right handed seven volunteers, activation of language areas was lateralized to the left side. Verb generation task produced stronger activation in the language areas and higher value of lateralization index than noun generation task or decision task. Conclusion : fMRI could be a useful non-invasive method for language mapping and determination of language dominance. 목적 : 언어기능의 지도화(language mapping) 및 우세반구 결정에 있어서 기능적 자기공명영상의 유용서을 알아보고자 하였다. 대상 및 방법 : 자원자 10명(남자 6명, 여자 4명, 오른손잡이 7명, 왼손잡이 3명)을 대상으로 단어생성 과제(명사만들기, 동사만들기)와 판단과제를 이용하여 언어영역의 활성화를 유도하였다. 1.5T 초진도 자기공명영상장치에서 EPI로 BOLD 기법을 이용하여 기능적 영상을 얻었으며, 여앙후처리는 SPM 분석 프로그램을 이용하였다. 기능적 영상은 2번의 활성기와 3번의 휴식기를 번갈아 시행하였고 스캔 시간은 각각30초였으며 총 영상획득시간은 162초였다. 유의수준 p