새로운 항암성 제리쿠드라닌 E 유도체의 합성 및 항암활성
The two gericudranin E derivatives, GER-I & II, were synthesized and evaluated their antitumour activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules GER-I and GER-B in 5 steps via sequential protection, aldol condensati...
Gespeichert in:
| Veröffentlicht in: | Yaghag-hoi-ji 1999-10, Vol.43 (5), p.559-565 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | kor |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 565 |
|---|---|
| container_issue | 5 |
| container_start_page | 559 |
| container_title | Yaghag-hoi-ji |
| container_volume | 43 |
| creator | 박재호(Jae Ho Park) 박경란(Kyoung Lan Park) 호현순(Hyun Soon Ho) 김희두(Hee Doo Kim) 표명윤(Myoung Yun Pyo) |
| description | The two gericudranin E derivatives, GER-I & II, were synthesized and evaluated their antitumour activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules GER-I and GER-B in 5 steps via sequential protection, aldol condensation, Michael type-cyclization, regioselective C-benzylation. The cellular growth inhibition of compounds GER-I and GER-II were investigated against P388, L1210, K562, HCT-15, SK-HepG-1, MCF-7 as cancer cell lines and mouse splenocytes as a normal cell by MTT assay. |
| format | Article |
| fullrecord | <record><control><sourceid>kyobo_kisti</sourceid><recordid>TN_cdi_kisti_ndsl_JAKO199911919478179</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4010024042243</sourcerecordid><originalsourceid>FETCH-LOGICAL-k603-2693bad782b0c60666bb5830ac6137d4ab93b608edd4d5c4e8411f44c39bf1553</originalsourceid><addsrcrecordid>eNpNjD1Lw0Acxg9RMNR-hyyOgbv73-tYSn2tdOkeckkKIaUB08XZDoJCBy2opBAXQVBQ6Sj4ge76HYzYwemB3_N7ni3kUVAQaMblNvIwSBlozsUuapdlZjAIKpUE7qEzd3llnyr3uPLXize3uHOzD9_VlX1-dd-1va3s8ste3_g931W1nc_c58ot7xv35Ve07_PNbP1QNWAP7YyicZm2N9lCw4PesHsU9AeHx91OP8gFhoAKDSZKpKIGxwILIYzhCnAUCwIyYZFpeoFVmiQs4TFLFSNkxFgM2owI59BC-3-3eVZOs3CSlOPwpHM6IFprQjTRTCoi9T_vojBFaIoij9PJND0PGSYYU4YZpQzgB73Wa7U</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>새로운 항암성 제리쿠드라닌 E 유도체의 합성 및 항암활성</title><source>Alma/SFX Local Collection</source><creator>박재호(Jae Ho Park) ; 박경란(Kyoung Lan Park) ; 호현순(Hyun Soon Ho) ; 김희두(Hee Doo Kim) ; 표명윤(Myoung Yun Pyo)</creator><creatorcontrib>박재호(Jae Ho Park) ; 박경란(Kyoung Lan Park) ; 호현순(Hyun Soon Ho) ; 김희두(Hee Doo Kim) ; 표명윤(Myoung Yun Pyo)</creatorcontrib><description>The two gericudranin E derivatives, GER-I & II, were synthesized and evaluated their antitumour activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules GER-I and GER-B in 5 steps via sequential protection, aldol condensation, Michael type-cyclization, regioselective C-benzylation. The cellular growth inhibition of compounds GER-I and GER-II were investigated against P388, L1210, K562, HCT-15, SK-HepG-1, MCF-7 as cancer cell lines and mouse splenocytes as a normal cell by MTT assay.</description><identifier>ISSN: 0377-9556</identifier><identifier>EISSN: 2383-9457</identifier><language>kor</language><publisher>The Pharmaceutical Society Of Korea</publisher><ispartof>Yaghag-hoi-ji, 1999-10, Vol.43 (5), p.559-565</ispartof><rights>COPYRIGHT(C) KYOBO BOOK CENTRE ALL RIGHTS RESERVED</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885</link.rule.ids></links><search><creatorcontrib>박재호(Jae Ho Park)</creatorcontrib><creatorcontrib>박경란(Kyoung Lan Park)</creatorcontrib><creatorcontrib>호현순(Hyun Soon Ho)</creatorcontrib><creatorcontrib>김희두(Hee Doo Kim)</creatorcontrib><creatorcontrib>표명윤(Myoung Yun Pyo)</creatorcontrib><title>새로운 항암성 제리쿠드라닌 E 유도체의 합성 및 항암활성</title><title>Yaghag-hoi-ji</title><addtitle>Yakhak hoeji</addtitle><description>The two gericudranin E derivatives, GER-I & II, were synthesized and evaluated their antitumour activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules GER-I and GER-B in 5 steps via sequential protection, aldol condensation, Michael type-cyclization, regioselective C-benzylation. The cellular growth inhibition of compounds GER-I and GER-II were investigated against P388, L1210, K562, HCT-15, SK-HepG-1, MCF-7 as cancer cell lines and mouse splenocytes as a normal cell by MTT assay.</description><issn>0377-9556</issn><issn>2383-9457</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>JDI</sourceid><recordid>eNpNjD1Lw0Acxg9RMNR-hyyOgbv73-tYSn2tdOkeckkKIaUB08XZDoJCBy2opBAXQVBQ6Sj4ge76HYzYwemB3_N7ni3kUVAQaMblNvIwSBlozsUuapdlZjAIKpUE7qEzd3llnyr3uPLXize3uHOzD9_VlX1-dd-1va3s8ste3_g931W1nc_c58ot7xv35Ve07_PNbP1QNWAP7YyicZm2N9lCw4PesHsU9AeHx91OP8gFhoAKDSZKpKIGxwILIYzhCnAUCwIyYZFpeoFVmiQs4TFLFSNkxFgM2owI59BC-3-3eVZOs3CSlOPwpHM6IFprQjTRTCoi9T_vojBFaIoij9PJND0PGSYYU4YZpQzgB73Wa7U</recordid><startdate>19991028</startdate><enddate>19991028</enddate><creator>박재호(Jae Ho Park)</creator><creator>박경란(Kyoung Lan Park)</creator><creator>호현순(Hyun Soon Ho)</creator><creator>김희두(Hee Doo Kim)</creator><creator>표명윤(Myoung Yun Pyo)</creator><general>The Pharmaceutical Society Of Korea</general><general>대한약학회</general><scope>P5Y</scope><scope>SSSTE</scope><scope>JDI</scope></search><sort><creationdate>19991028</creationdate><title>새로운 항암성 제리쿠드라닌 E 유도체의 합성 및 항암활성</title><author>박재호(Jae Ho Park) ; 박경란(Kyoung Lan Park) ; 호현순(Hyun Soon Ho) ; 김희두(Hee Doo Kim) ; 표명윤(Myoung Yun Pyo)</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-k603-2693bad782b0c60666bb5830ac6137d4ab93b608edd4d5c4e8411f44c39bf1553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>1999</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>박재호(Jae Ho Park)</creatorcontrib><creatorcontrib>박경란(Kyoung Lan Park)</creatorcontrib><creatorcontrib>호현순(Hyun Soon Ho)</creatorcontrib><creatorcontrib>김희두(Hee Doo Kim)</creatorcontrib><creatorcontrib>표명윤(Myoung Yun Pyo)</creatorcontrib><collection>Kyobo Scholar (교보스콜라)</collection><collection>Scholar(스콜라)</collection><collection>KoreaScience</collection><jtitle>Yaghag-hoi-ji</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>박재호(Jae Ho Park)</au><au>박경란(Kyoung Lan Park)</au><au>호현순(Hyun Soon Ho)</au><au>김희두(Hee Doo Kim)</au><au>표명윤(Myoung Yun Pyo)</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>새로운 항암성 제리쿠드라닌 E 유도체의 합성 및 항암활성</atitle><jtitle>Yaghag-hoi-ji</jtitle><addtitle>Yakhak hoeji</addtitle><date>1999-10-28</date><risdate>1999</risdate><volume>43</volume><issue>5</issue><spage>559</spage><epage>565</epage><pages>559-565</pages><issn>0377-9556</issn><eissn>2383-9457</eissn><abstract>The two gericudranin E derivatives, GER-I & II, were synthesized and evaluated their antitumour activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules GER-I and GER-B in 5 steps via sequential protection, aldol condensation, Michael type-cyclization, regioselective C-benzylation. The cellular growth inhibition of compounds GER-I and GER-II were investigated against P388, L1210, K562, HCT-15, SK-HepG-1, MCF-7 as cancer cell lines and mouse splenocytes as a normal cell by MTT assay.</abstract><pub>The Pharmaceutical Society Of Korea</pub><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0377-9556 |
| ispartof | Yaghag-hoi-ji, 1999-10, Vol.43 (5), p.559-565 |
| issn | 0377-9556 2383-9457 |
| language | kor |
| recordid | cdi_kisti_ndsl_JAKO199911919478179 |
| source | Alma/SFX Local Collection |
| title | 새로운 항암성 제리쿠드라닌 E 유도체의 합성 및 항암활성 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T06%3A23%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-kyobo_kisti&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=%EC%83%88%EB%A1%9C%EC%9A%B4%20%ED%95%AD%EC%95%94%EC%84%B1%20%EC%A0%9C%EB%A6%AC%EC%BF%A0%EB%93%9C%EB%9D%BC%EB%8B%8C%20E%20%EC%9C%A0%EB%8F%84%EC%B2%B4%EC%9D%98%20%ED%95%A9%EC%84%B1%20%EB%B0%8F%20%ED%95%AD%EC%95%94%ED%99%9C%EC%84%B1&rft.jtitle=Yaghag-hoi-ji&rft.au=%EB%B0%95%EC%9E%AC%ED%98%B8(Jae%20Ho%20Park)&rft.date=1999-10-28&rft.volume=43&rft.issue=5&rft.spage=559&rft.epage=565&rft.pages=559-565&rft.issn=0377-9556&rft.eissn=2383-9457&rft_id=info:doi/&rft_dat=%3Ckyobo_kisti%3E4010024042243%3C/kyobo_kisti%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |