새로운 항암성 제리쿠드라닌 E 유도체의 합성 및 항암활성

새로운 항암성 제리쿠드라닌 E 유도체의 합성 및 항암활성

The two gericudranin E derivatives, GER-I & II, were synthesized and evaluated their antitumour activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules GER-I and GER-B in 5 steps via sequential protection, aldol condensati...

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Veröffentlicht in:Yaghag-hoi-ji 1999-10, Vol.43 (5), p.559-565
Hauptverfasser: 박재호(Jae Ho Park), 박경란(Kyoung Lan Park), 호현순(Hyun Soon Ho), 김희두(Hee Doo Kim), 표명윤(Myoung Yun Pyo)
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Sprache:kor
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Zusammenfassung:The two gericudranin E derivatives, GER-I & II, were synthesized and evaluated their antitumour activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules GER-I and GER-B in 5 steps via sequential protection, aldol condensation, Michael type-cyclization, regioselective C-benzylation. The cellular growth inhibition of compounds GER-I and GER-II were investigated against P388, L1210, K562, HCT-15, SK-HepG-1, MCF-7 as cancer cell lines and mouse splenocytes as a normal cell by MTT assay.
ISSN:0377-9556
2383-9457